Prosci/4-1BB Recombinant Protein/96-790/100 ug,ProSci,,ProSci,prosci-inc,ProSci Incorporated,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Prosci/4-1BB Recombinant Protein/96-790/100 ug

产品编号：96-790

市场价：¥9500.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>其它重组蛋白>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$475.00

品牌： ProSci

公司：ProSci Inc

公司分类：

商品介绍

Specifications

SPECIES:	Cynomolgus,Rhesusmacaque
SOURCESPECIES:	HEK293cells
SEQUENCE:	Leu24-Gln186
FUSIONTAG:	HisTag
TESTEDAPPLICATIONS:	ELISA,WB
APPLICATIONS:	ThisrecombinantproteincanbeusedforE,WB.Forresearchuseonly.
BIOLOGICALACTIVITY:	MeasuredbyitsbindingABIlityinafunctionalELISA.ImmobilizedCynomolgus/Rhesusmacaque4-1BB,HisTagat1ug/mL(100uL/well)canbindHuman4‑1BBLigand,FcTagwithalinearrangeof0.05-0.5ng/mL(QCtested).

Properties

PURITY:	>92%asdeterminedbySDS-PAGE. Endotoxinlevelislessthan1.0EUperugbytheLALmethod.
PREDICTEDMOLECULARWEIGHT:	19.2kDa
PHYSICALSTATE:	Lyophilized
BUFFER:	PBS,pH7.4
STORAGECONDITIONS:	LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles.

AdditionalInfo

ALTERNATENAMES:	4-1BB
ACCESSIONNO.:	XP_005544945.1

Background

4-1BBisalsoknownasCD137,tumornecrosisfactorreceptorsuperfamilymember9(TNFRSF9),inducedbylymphocyteactivation(ILA),isaco-stimulatorymoleculeofthetumornecrosisfactor(TNF)receptorsuperfamily.CD137canbeexpressedbyactivatedTcells,buttoalargerextentonCD8thanonCD4Tcells.Inaddition,CD137expressionisfoundondendriticcells,folliculardendriticcells,naturalkillercells,granulocytesandcellsofbloodvesselwallsatsitesofinflammation.ThebestcharacterizedactivityofCD137isitscostimulatoryactivityforactivatedTcells.CrosslinkingofCD137enhancesTcellproliferation,IL-2secretionsurvivalandcytolyticactivity.Further,itcanenhanceimmuneactivitytoeliminatetumorsinmice.CD137canenhanceactivation-inducedTcellapoptosiswhentriggeredbyengagementoftheTCR/CD3complex.Inaddition,4-1BB/4-1BBLco-stimulatorypathwayhasbeenshowntoaugmentsecondaryCTLresponsestoseveralviruses,andmeanwhileaugmentanti-tumorimmunity.4-1BBthusisapromisingcandidateforimmunotherapyofhumancancer.CD137hasbeenshowntointeractwithTRAF2.

品牌介绍

ProSci Inc.始终开放以支持研究需求，同时确保我们员工的健康和安全。ProSci拥有广泛的冠状病毒SARS-CoV-2 重组蛋白和抗体产品组合，并将继续积极开发新的冠状病毒产品。此外，ProSci的定制抗体服务也保持开放状态，以支持研究团体开发研究工具，诊断，疗法和疫苗。