Prosci/BID Recombinant Protein/91-089/0.05 mg,ProSci,,ProSci,prosci-inc,ProSci Incorporated,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Prosci/BID Recombinant Protein/91-089/0.05 mg

产品编号：91-089

市场价：¥7500.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>其它重组蛋白>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$375.00

品牌： ProSci

公司：ProSci Inc

公司分类：

商品介绍

Specifications

SPECIES:	Human
SOURCESPECIES:	E.coli
SEQUENCE:	Met1-Asp195
FUSIONTAG:	TagFree
TESTEDAPPLICATIONS:
APPLICATIONS:	ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly.

Properties

PURITY:	Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest.
PREDICTEDMOLECULARWEIGHT:	21.99kD
PHYSICALSTATE:	Liquid
BUFFER:	Suppliedasa0.2umfilteredsolutionof20mMPB,100mMKCl,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O.
STORAGECONDITIONS:	Storeat-20˚C,stablefor6monthsafterreceipt. Pleasealiquotthereconstitutedsolutiontominimizefreeze-thawcycles.

AdditionalInfo

ALTERNATENAMES:	BH3-InteractingDomainDeathAgoNIST,p22BID,BID
ACCESSIONNO.:	P55957

Background

BH3-InteractingDomainDeathAgonist(BID)isamemberoftheBcl-2proteinfamilywhichregulatesoutermitochondrialmembranepermeABIlity.BIDisapro-apoptoticmemberthatcausescytochromectobereleasedfromthemitochondriaintermembranespaceintothecytosol.InteractionofBidwithBakcausesalteredmitochondrialmembranepermeability.BIDcontainsonlytheBH3domain,whichisrequiredforitsinteractionwiththeBcl-2familyproteinsandforitspro-deathactivity.BIDissusceptIBLetoproteolyticcleavagebycaspases,calpains,GranzymeBandcathepsins.Itisanintegratingkeyregulatoroftheintrinsicdeathpathwaythatamplifiescaspase-dependentandcaspase-independentexecutionofneuronalapoptosis.ThereforepharmacologicalinhibitionofBIDprovidesapromisingtherapeuticstrategyinneurologicaldiseaseswhereprogrammedcelldeathisprominent,andalsoofferanewstrategyforthetreatmentofacuterenalfailureassociatedwithischemia-reperfusion.BIDreceivesdirectinputsfromakeyregulatorofthecellcyclearrest/DNArepairmachinery(ATM),andthereforeisanexcellentcandidatetocoordinategenotoxicstressresponsesandapoptoticcelldeath.BIDisanovelpro-apoptosisBcl-2familyproteinthatisactivatedbycaspase8inresponsetoFas/TNF-R1deathreceptorsignals.DeletionofBIDinhibitscarcinogenesisintheliver,althoughthisgeneticalterationpromotestumOrigenesisinthemyeloidcells.ThisislikelyrelatedtothefunctionofBIDtopromotecellcycleprogressionintoSphase.BIDcouldbealsoinvolvedinthemaintenanceofgenomicstabilitybyengagingatmitosischeckpoint.

品牌介绍

ProSci Inc.始终开放以支持研究需求，同时确保我们员工的健康和安全。ProSci拥有广泛的冠状病毒SARS-CoV-2 重组蛋白和抗体产品组合，并将继续积极开发新的冠状病毒产品。此外，ProSci的定制抗体服务也保持开放状态，以支持研究团体开发研究工具，诊断，疗法和疫苗。