SPECIES: | Human |
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SOURCESPECIES: | E.coli |
SEQUENCE: | Ile141-Val247 |
FUSIONTAG: | N-Trxtag |
TESTEDAPPLICATIONS: | |
APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
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PREDICTEDMOLECULARWEIGHT: | 29.4kD |
PHYSICALSTATE: | Lyophilized |
BUFFER: | Lyophilizedfroma0.2umfilteredsolutionof20mMPB,150mMNaCl,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
STORAGECONDITIONS: | Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks. Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days. Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months. |
ALTERNATENAMES: | ATP-bindingcassettesub-familyBmember5,P-glycoproteinABCB5,ABCB5P-gp,ABCB5 |
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ACCESSIONNO.: | Q2M3G0 |
ATP-bindingcassettesub-familyBmember5(ABCB5)isaplasmamembrane-spanningprotein.ABCB5isprincipallyexpressedinphysiologicalskinandhumanmalignantmelanoma.ABCB5hasbeensuggestedtoregulateskinProgenitorcellfusionandmediatechemotherapeuticdrugresistanceinstem-liketumorcellsubpopulationsinhumanmalignantmelanoma.Itiscommonlyover-expressedoncirculatingmelanomatumourcells.FurThermore,theABCB5+melanoma-initiatingcellsweredemonstratedtoexpressFLT1(VEGFR1)receptortyrosinekinasewhichwasfunctionallyrequiredforefficientxenografttumorformation,asdemonstratedbyshRNAknockdownexperiments. |
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