SPECIES: | Mouse |
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SOURCESPECIES: | HumanCells |
SEQUENCE: | Ser21-Ser114 |
FUSIONTAG: | C-6Histag |
TESTEDAPPLICATIONS: | |
APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
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PREDICTEDMOLECULARWEIGHT: | 11.2kD |
PHYSICALSTATE: | Lyophilized |
BUFFER: | Lyophilizedfroma0.2umfilteredsolutionof20mMPB,150mMNaCl,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
STORAGECONDITIONS: | Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks. Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days. Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months. |
ALTERNATENAMES: | Resistin,Retn,ADIposetissue-specificsecretoryfactor,ADSF,Adipose-specificcysteine-richsecretedproteinA12-alpha,Cysteine-richsecretedproteinFIZZ3,Fizz3 |
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ACCESSIONNO.: | Q99P87 |
Resistinisacysteine-richadipose-derivedpeptidehormone,whichbelongstotheresistin/FIZZfamily.Resistinhasbeenshowntocausehighlevelsof"bad"cholesterol(low-densitylipoproteinorLDL),increasingtheriskofheartdisease,resistinincreasestheproductionofLDLinhumanlivercellsandalsodegradesLDLreceptorsintheliver.Asaresult,theliverislessabletoclear"bad"cholesterolfromthebody.ResistinacceleratestheaccumulationofLDLinarteries,increasingtheriskofheartdisease,resistinadverselyimpactstheeffectsofstatins,themaincholesterol-reducingdrugusedinthetreatmentandpreventionofcardiovasculardisease. |
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