Prosci/ABAT Antibody/26-612/50 ug,ProSci,,ProSci,prosci-inc,ProSci Incorporated,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Prosci/ABAT Antibody/26-612/50 ug

产品编号：26-612

市场价：¥6500.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>重组抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$325.00

品牌： ProSci

公司：ProSci Inc

公司分类：

商品介绍

Specifications

SPECIES REACTIVITY:	Mouse, Rat
TESTED APPLICATIONS:	WB
APPLICATIONS:	ABAT antibody can be used for detection of ABAT by ELISA at 1:12500. ABAT antibody can be used for detection of ABAT by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
USER NOTE:	Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:	1) Cat. No. 1309 - Human Placenta Lysate
PREDICTED MOLECULAR WEIGHT:	55 kDa
IMMUNOGEN:	Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ABAT.
HOST SPECIES:	Rabbit

Properties

PURIFICATION:	Antibody is purified by peptide affinity chromatography method.
PHYSICAL STATE:	Lyophilized
BUFFER:	Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
CONCENTRATION:	1 mg/ml
STORAGE CONDITIONS:	For short periods of storage (days) store at 4˚C. For longer periods of storage, store ABAT antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
CLONALITY:	Polyclonal
CONJUGATE:	Unconjugated

Additional Info

ALTERNATE NAMES:	ABAT, GABA-AT, GABAT, NPD009
ACCESSION NO.:	NP_065737
PROTEIN GI NO.:	38679946
OFFICIAL SYMBOL:	ABAT
GENE ID:	18

Background

BACKGROUND:	4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
REFERENCES:	1) Inada, T., (2008) Pharmacogenet. Genomics 18 (4), 317-323.

BACKGROUND:

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

REFERENCES:

1) Inada, T., (2008) Pharmacogenet. Genomics 18 (4), 317-323.

品牌介绍

ProSci Inc.始终开放以支持研究需求，同时确保我们员工的健康和安全。ProSci拥有广泛的冠状病毒SARS-CoV-2 重组蛋白和抗体产品组合，并将继续积极开发新的冠状病毒产品。此外，ProSci的定制抗体服务也保持开放状态，以支持研究团体开发研究工具，诊断，疗法和疫苗。