SPECIES: | Mouse |
---|---|
SOURCESPECIES: | HumanCells |
SEQUENCE: | Val38-Lys245 |
FUSIONTAG: | C-Fctag |
TESTEDAPPLICATIONS: | |
APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
---|---|
PREDICTEDMOLECULARWEIGHT: | 50.8kD |
PHYSICALSTATE: | Lyophilized |
BUFFER: | Lyophilizedfroma0.2umfilteredsolutionofPBS,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
STORAGECONDITIONS: | Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks. Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days. Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months. |
ALTERNATENAMES: | T-lymphocyteactivationantigenCD80,ActivationB7-1antigen,B7,CD80 |
---|---|
ACCESSIONNO.: | Q00609 |
ClusterofDifferentiation80,alsocalledB7-1,isamemberofcellsurfaceimmunoglobulinsuperfamilywhichplayskey,yetdistinctrolesintheactivationofTcells.ItistheligandfortwodifferentproteinsontheTcellsurface:CD28andCTLA-4.StudieshaveshownthatCTLA-4bindsmostlytoCD80.Thestructurepresentstwoextracellulardomains:amembranedistalvariable-likedomain(IgV)andamembraneproximalIgconstant-likedomain(IgC)alongwithanintracellulardomain.BothIgVandIgCconsistofanti-parallelbetasandwichesjoinedbyashortlinkerregion.CD80ismostlyexpressedonthesurfaceofantigen-presentingcellsincludingactivatedBcells,macrophagesanddendriticcells. |
ProSci Inc.始终开放以支持研究需求,同时确保我们员工的健康和安全。ProSci拥有广泛的冠状病毒SARS-CoV-2 重组蛋白和抗体产品组合, 并将继续积极开发新的冠状病毒 产品。此外,ProSci的定制抗体服务也保持开放状态,以支持研究团体开发 研究工具,诊断,疗法和疫苗。