| SPECIES: | Mouse |
|---|---|
| SOURCESPECIES: | HEK293cells |
| SEQUENCE: | Val29-Phe244 |
| FUSIONTAG: | HisTag |
| TESTEDAPPLICATIONS: | WB |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforWB.Forresearchuseonly. |
| PURITY: | >95%asdeterminedbySDS-PAGE. Endotoxinlevelislessthan1.0EUperugbytheLALmethod. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 25.4kDa |
| PHYSICALSTATE: | Lyophilized |
| BUFFER: | PBS,pH7.4 |
| STORAGECONDITIONS: | LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles. |
| ALTERNATENAMES: | B7-H3,CD276,B7homolog3 |
|---|---|
| ACCESSIONNO.: | NP_598744 |
| B7homolog3(B7-H3),amemberoftheimmunoglobulinsuperfamily,isalsoknownCD276,whichcontainstwoIg-likeC2-type(immunoglobulin-like)domainsandtwoIg-likeV-type(immunoglobulin-like)domains.B7-H3mayparticipateintheregulationofT-cell-mediatedimmuneresponse.B7-H3alsoplaysaprotectiveroleintumorcellsbyinhibitingnatural-killermediatedcelllysisaswellasaroleofMarkerfordetectionofneuroblastomacells.FurThermore,B7-H3isinvolvedinthedevelopmentofacuteandchronictransplantrejectionandintheregulationoflymphocyticactivityatmucosalsurfaces.Itcouldalsoplayakeyroleinprovidingtheplacentaandfetuswithasuitableimmunologicalenvironmentthroughoutpregnancy. |
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