SPECIES: | Mouse |
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SOURCESPECIES: | HEK293cells |
SEQUENCE: | Val29-Phe244 |
FUSIONTAG: | HisTag |
TESTEDAPPLICATIONS: | WB |
APPLICATIONS: | ThisrecombinantproteincanbeusedforWB.Forresearchuseonly. |
PURITY: | >95%asdeterminedbySDS-PAGE. Endotoxinlevelislessthan1.0EUperugbytheLALmethod. |
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PREDICTEDMOLECULARWEIGHT: | 25.4kDa |
PHYSICALSTATE: | Lyophilized |
BUFFER: | PBS,pH7.4 |
STORAGECONDITIONS: | LyophilizedProteinshouldbestoredat-20˚Corlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20˚Cor-70˚C.Avoidrepeatedfreeze-thawcycles. |
ALTERNATENAMES: | B7-H3,CD276,B7homolog3 |
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ACCESSIONNO.: | NP_598744 |
B7homolog3(B7-H3),amemberoftheimmunoglobulinsuperfamily,isalsoknownCD276,whichcontainstwoIg-likeC2-type(immunoglobulin-like)domainsandtwoIg-likeV-type(immunoglobulin-like)domains.B7-H3mayparticipateintheregulationofT-cell-mediatedimmuneresponse.B7-H3alsoplaysaprotectiveroleintumorcellsbyinhibitingnatural-killermediatedcelllysisaswellasaroleofMarkerfordetectionofneuroblastomacells.FurThermore,B7-H3isinvolvedinthedevelopmentofacuteandchronictransplantrejectionandintheregulationoflymphocyticactivityatmucosalsurfaces.Itcouldalsoplayakeyroleinprovidingtheplacentaandfetuswithasuitableimmunologicalenvironmentthroughoutpregnancy. |
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