SPECIES: | Human |
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SOURCE SPECIES: | E. coli |
SEQUENCE: | AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA |
TESTED APPLICATIONS: |
PURITY: | Greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
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PHYSICAL STATE: | Lyophilized |
STORAGE CONDITIONS: | The lyophilized BCMA recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted BCMA is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing BCMA recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
ALTERNATE NAMES: | BCM, BCMA, CD269, TNFRSF13A, BCM, Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein |
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ACCESSION NO.: | NP_001183.2 |
PROTEIN GI NO.: | 23238192 |
BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines and plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid extracellular domain. Recombinant soluble BCMA is a 50 amino acid polypeptide (5.3 kDa) comprising the TNFR homologous region of the BCMA protein. |
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