SPECIESREACTIVITY: | Human |
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HOMOLOGY: | Predictedspeciesreactivitybasedonimmunogensequence:Bovine |
TESTEDAPPLICATIONS: | IHC-P,WB |
APPLICATIONS: | ForWBstartingdilutionis:1:1000 ForIHC-Pstartingdilutionis:1:50~100 |
USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
PREDICTEDMOLECULARWEIGHT: | 115kDa |
IMMUNOGEN: | ThisACK1antibodyisgeneratedfromrabbitsimmunizedwithaKLHconjugatedsyntheticpeptidebetween934-964aminoacidsfromtheC-terminalregionofhumanACK1. |
HOSTSPECIES: | Rabbit |
PURIFICATION: | ThisantibodyispurifiedthroughaproteinAcolumn,followedbypeptideaffinitypurification. |
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PHYSICALSTATE: | Liquid |
BUFFER: | SuppliedinPBSwith0.09%(W/V)sodiumazide. |
CONCENTRATION: | 0.42mg/ml |
STORAGECONDITIONS: | Storeat4˚Cforthreemonthsand-20˚C,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures. |
CLONALITY: | Polyclonal |
ISOTYPE: | RabbitIg |
CONJUGATE: | Unconjugated |
ALTERNATENAMES: | ActivatedCDC42kinase1,ACK-1,Tyrosinekinasenon-receptorprotein2,TNK2,ACK1 |
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ACCESSIONNO.: | Q07912 |
PROTEINGINO.: | 229462980 |
OFFICIALSYMBOL: | TNK2 |
GENEID: | 10188 |
BACKGROUND: | ACK1isatyrosinekinasethatbindsCdc42HsinitsGTP-boundformandinhibitsboththeintrinsicandGTPase-activatingprotein(GAP)-stimulatedGTPaseactivityofCdc42Hs.Thisbindingismediatedbyauniquesequenceof47aminoacidsC-terminaltoanSH3domain.TheproteinmaybeinvolvedinaregulatorymechanismthatsustainstheGTP-boundactiveformofCdc42Hsandwhichisdirectlylinkedtoatyrosinephosphorylationsignaltransductionpathway. |
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REFERENCES: | 1)Yokoyama,N.,etal.,J.Biol.Chem.278(48):47713-47723(2003). | 2)Manser,E.,etal.,Nature363(6427):364-367(1993). |
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