SPECIES: | Human |
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SOURCE SPECIES: | HEK293 cells |
SEQUENCE: | Asp 32 - Tyr 111 |
FUSION TAG: | Fc Tag |
TESTED APPLICATIONS: | WB |
APPLICATIONS: | This recombinant protein can be used for WB. For research use only. |
PURITY: | >92% as determined by reduced SDS-PAGE. Endotoxin level is less than 1.0 EU per ug by the LAL method. |
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PREDICTED MOLECULAR WEIGHT: | 36.5 kDa |
PHYSICAL STATE: | Lyophilized |
BUFFER: | 50 mM Tris, 100 mM Glycine, pH7.5 |
STORAGE CONDITIONS: | Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles. |
ALTERNATE NAMES: | betacellulin,BTC |
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ACCESSION NO.: | AAH11618 |
Probetacellulin can be cleaved into the Betacellulin (BTC) that is a single-pass type I membrane protein containing 1 EGF-like domain. Predominantly expressed in pancreas and small intestine,Betacellulin (BTC) is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. As a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells, Betacellulin (BTC) is also the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Betacellulin (BTC) was originally identified as a growth-promoting factor in mouse pancreatic beta-cell carcinoma cell line and has since been identified in humans. The amino acid sequence of mature mBTC is 82.5%, identical with that of human BTC (hBTC), and both exhibit significant overall similarity with other members of the EGF family. |
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