SPECIES: | Human |
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SOURCESPECIES: | HEK293cells |
SEQUENCE: | Humanbetatrophin(22-198)isfusedattheC-terminustotheFcportionofhumanIgG1. |
FUSIONTAG: | FcTag |
TESTEDAPPLICATIONS: | |
APPLICATIONS: | Thisrecombinantproteinsisforresearchuseonly. |
BIOLOGICALACTIVITY: | N/A |
PURITY: | >90%(SDS-PAGE) |
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PHYSICALSTATE: | Lyophilized |
BUFFER: | ContainsPBS+0.02%CHAPS. |
CONCENTRATION: | 0.1mg/mlafterreconstitution. |
STORAGECONDITIONS: | Stableforatleast6monthsafterreceiptwhenstoredat-20˚C. |
ALTERNATENAMES: | Angiopoietin-likeProtein8,ANGPTL8,Lipasin,Refeeding-inducedFatandLiverProtein,RIFL |
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ACCESSIONNO.: | Q6UXH0 |
PROTEINGINO.: | 291219911 |
Betatrophin(RIFL;Lipasin;Angiopoietin-likeprotein8(ANGPTL8))isanewlydiscoveredsecretedproteinof198aathatwasproposedtopromotebetacellproliferationandimproveglucosetoleranceinmice.Betatrophinmayalsofunctionininhibitionoflipaseactivityandonserumtriglycerideregulation.BetatrophinisexpressedintheliverandinwhiteandbrownADIposetissueofmice.Inhumans,betatrophinisfoundtobepredominantlyexpressedintheliver.Betatrophinlevelsarereducedbyfastingandareelevateduponinsulinresistanceandduringpregnancy.Betatrophin,accordingtopreliminarydatacouldbindtothemacrophagereceptorMarcoandalsotoRTN4R,aneuronalreceptor.Recently,astudyusingANGPTL8KOmiceshowedthatANGPTL8/Betatrophindoesnotplayaroleinbetacellproliferationnoringlycemiccontrolaspreviouslythought,butregulatesplasmatriglyceridelevels. |
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