SPECIES REACTIVITY: | Human, Mouse, Rat |
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TESTED APPLICATIONS: | ELISA, WB |
APPLICATIONS: | ABCC9 antibody can be used for detection of ABCC9 by ELISA at 1:1562500. ABCC9 antibody can be used for detection of ABCC9 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000. |
USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
POSITIVE CONTROL: | 1) 721_B Cell Lysate |
PREDICTED MOLECULAR WEIGHT: | 174 kDa |
IMMUNOGEN: | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ABCC9. |
HOST SPECIES: | Rabbit |
PURIFICATION: | Antibody is purified by peptide affinity chromatography method. |
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PHYSICAL STATE: | Lyophilized |
BUFFER: | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
CONCENTRATION: | 1 mg/ml |
STORAGE CONDITIONS: | For short periods of storage (days) store at 4˚C. For longer periods of storage, store ABCC9 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
CLONALITY: | Polyclonal |
CONJUGATE: | Unconjugated |
ALTERNATE NAMES: | ABCC9, ABC37, CMD1O, FLJ36852, SUR2, CANTU, ATFB12 |
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ACCESSION NO.: | NP_005682 |
PROTEIN GI NO.: | 110832835 |
OFFICIAL SYMBOL: | ABCC9 |
GENE ID: | 10060 |
BACKGROUND: | ABCC9 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. No disease has been associated with this gene thus far. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. No disease has been associated with this gene thus far. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion. |
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REFERENCES: | 1) Burke, M.A., (2008) Circ. Res. 102 (2), 164-176. |
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